Spikeweed may refer to:
- Spikeweed, a plant in Plants vs. Zombies and Plants vs. Zombies 2.
- Spikeweed, a plant and ability in Plants vs. Zombies: Garden Warfare and Plants vs. Zombies: Garden Warfare 2.
- Spikeweed, a Tier 1 plant in Plants vs. Zombies: All Stars.
- Spikeweed Sector, an Environment card in Plants vs. Zombies Heroes.