Due to its lack of strength and its low health, Lil' Buddy's main purpose is to act as a weak shield against zombies, which could save an expensive or valuable plant. If you are low in health, you could also play it to restore your health.
For examples of synergies with other plants, it can be used with Spineapple and Pecanolith to fight back. Alternatively, it can be used as "cannon fodder" to trigger Briar Rose's ability, and if it survives for a turn, it can be used for Template:PvZHLink's ability to restore your health. However, only Wall-Knight can normally use this combo.
Against
This plant will mainly block attacks from your zombies, but it is easy to take out. As long as it isn't boosted, any attack can destroy it. If you have zombies with the Frenzy or Strikethrough traits, using them will allow you to both destroy the Lil' Buddy and attack the plant hero. However, if Briar Rose is on the field, then this can cause a problem and spell disaster for both you and your zombies, as Lil' Buddy is also a flower. So if there is one, then it is recommended to destroy it with other cards before your zombies attack the Lil' Buddies. Alternatively, you could also use Weed Spray or The Chickening to get rid of all the Lil' Buddies without worrying about Briar Rose's ability.
Solar class. It is made by Poppin' Poppies, but can also be made by Cornucopia's ability, Conjured by Cosmic Flower, or transformed into by Seedling, Petal-Morphosis, or Reincarnation's ability. It costs 1
to play (only when it is Bounced or transformed into by Reincarnation), and has 1
. It has the Team-Up trait, and its ability heals the plant hero for 2
Guardian → Solar
Frenzy or 
Strikethrough traits, using them will allow you to both destroy the Lil' Buddy and attack the plant hero. However, if Briar Rose is on the field, then this can cause a problem and spell disaster for both you and your zombies, as Lil' Buddy is also a flower. So if there is one, then it is recommended to destroy it with other cards before your zombies attack the Lil' Buddies. Alternatively, you could also use Weed Spray or The Chickening to get rid of all the Lil' Buddies without worrying about Briar Rose's ability.
frozen
/24
Kabloom
Mega-Grow
Smarty
Solar